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Detroit (/ d ɪ ˈ t r ɔɪ t /, dih-TROYT; locally also / ˈ d iː t r ɔɪ t /, DEE-troyt) [8] is the most populous city in the U.S. state of Michigan.It is the largest U.S. city on the Canadian border and the county seat of Wayne County.
Some 25% of out-of-pocket spending by individuals is for prescription drugs. [283] Another study finds that between 1990 and 2016, prescription drug prices in the US increased by 277% while prescription drug prices increased by only 57% in the UK, 13% in Canada, and decreased in France and Japan. [ 284 ]
Another representative study, published in 1999 by the German Institut für rationale Psychologie, found that about 2/3 of the interviewed women stated a desire to be at the mercy of their sexual partners from time to time. 69% admitted to fantasies dealing with sexual submissiveness, 42% stated interest in explicit BDSM techniques, 25% in ...
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