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Methicillin-resistant Staphylococcus aureus (MRSA, often pronounced / ˈmɜːrsə / or / ɛm ɑːr ɛs eɪ / ), is one of a number of greatly feared strains of S. aureus which have become resistant to most β-lactam antibiotics. For this reason, vancomycin, a glycopeptide antibiotic, is commonly used to combat MRSA.