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The London and North Western Railway (LNWR) Class G2A was a class of 0-8-0 steam locomotives. They were upgraded from LNWR Class G1 principally by the fitting of a higher pressure boiler . Some of the G2As subsequently received lower pressure boilers on overhaul, taking them back into Class G1.
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It is an immediate descendant of G2a (G-P15), which is a primary branch of haplogroup G2 (P287). G2a1 has an extremely low frequency in almost all populations except parts of the Caucasus Mountains. In 2017, the SNP L293 was replaced by FGC7535, SK1106 and Z6552 as the defining SNPs of G2a1, due to the technical difficulty in testing for L293. [1]
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G2A in humans is encoded by the GPR132 gene. [6] [7] The G2A gene is located on chromosome 14q32.3 codes for two alternative splice variants, the original one, G2A-a, and G2A-b, that consist of 380 and 371 amino acids, respectively; the two receptor variants, when expressed in Chinese hamster ovary cells, gave very similar results when analyzed for functionality. [8]
In descending order, G-P303 is additionally a branch of G2 (P287), G2a (P15), G2a2, G2a2b, G2a2b2, and finally G2a2b2a. This haplogroup represents the majority of haplogroup G men in most areas of Europe west of Russia and the Black Sea .