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2,5-Hexanedione reacts with lysine residues in axonal proteins by Schiff base formation followed by cyclization to give pyrroles. Oxidation of the pyrrole residues then causes cross-linking and denaturation of proteins, which perturbs axonal transport and function and causes damage to nerve cells.
The Master is a 2012 American psychological drama film written and directed by Paul Thomas Anderson and starring Joaquin Phoenix, Philip Seymour Hoffman, and Amy Adams.It tells the story of Freddie Quell (Phoenix), a World War II Navy veteran struggling to adjust to a post-war society, who meets Lancaster Dodd (Hoffman), the leader of a cult known as The Cause.
Pirate democracy was flexible but unable to deal with long-term dissent from the crew. [7] One description of the ritual of the pirate's code was in Alexandre Exquemelin's Buccaneers of America, published in 1678. Pirates called a first council (which included all crew members) to decide where to get provisions. Then they raided for supplies.
The second season of the tattoo reality competition Ink Master premiered on Spike on October 9 and concluded December 18, 2012 with a total of 13 episodes. The show is hosted and judged by Jane's Addiction guitarist Dave Navarro, with accomplished tattoo artists Chris Núñez and Oliver Peck serving as series regular judges.
ChatGPT is a chatbot and virtual assistant developed by OpenAI and launched on November 30, 2022. Based on large language models (LLMs), it enables users to refine and steer a conversation towards a desired length, format, style, level of detail, and language. [2]
This story was updated to reflect standings as of Friday, Sept. 20 at 8:00 a.m., as well as correct tiebreaker scenarios. As the MLB postseason draws nearer, fans are shaking, waiting for playoff ...
Piracy in the Gulf of Guinea affects a number of countries in West Africa as well as the wider international community. By 2011, it had become an issue of global concern. [1] [2] Pirates in the Gulf of Guinea are often part of heavily armed criminal enterprises, who employ violent methods to steal oil cargo. [3]
Manchester coding is a special case of binary phase-shift keying (BPSK), where the data controls the phase of a square wave carrier whose frequency is the data rate. . Manchester code ensures frequent line voltage transitions, directly proportional to the clock rate; this helps clock
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